Staff Site Reliability Engineer

About this role

Location: Oxford or London (Hybrid)

THE MISSION: WHY WE EXIST

Genomics is a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. We are united by a single vision to help people live longer healthier lives, using the power of genomics.

Genomics aims to help people live longer, healthier lives in two ways: super-charging drug discovery and development for novel treatments with our AI-enabled advanced genetic analytics platform, and by helping people understand their personal risk of common chronic diseases through polygenic risk scores - giving doctors and health systems the chance to get the right people into the right prevention, screening and treatment programmes at the right time.

ROLE PURPOSE

Genomics runs on multi-trillion-row, petabyte-scale genetic and health data. Mystra is the analytical data platform that makes that usable, and MystraAI is the agentic layer we are building on top of it. This is a Staff-level role that owns the reliability, performance, security and integrity of that infrastructure end-to-end — and sets the technical direction that other teams build on.

You will lead the analytical data platform and our Data-as-a-Service offering, shape the data foundations behind MystraAI, and line-manage a small team of engineers while staying deeply hands-on. If you want your work to sit at the intersection of large-scale infrastructure and genuinely meaningful science, this is it.

A DAY IN THE LIFE

The role spans the full depth of the platform — from low-level infrastructure reliability and database internals up to the systems that serve data across the product. On any given day you might be:

- Architecting, tuning and operating multi-tenant ClickHouse or equivalent OLAP database clusters at multi-trillion-row, petabyte scale — sharding and replication, materialised views, merge and query optimisation, tenant isolation and cost/performance trade-offs.

- Owning SLOs, observability, capacity planning and incident response for data-intensive systems and pipelines, alongside the orchestration and job execution that power them.

- Shaping Data-as-a-Service as a real product — a secure, multi-tenant, immutable release architecture, with data made discoverable at scale through catalogue and ontology-driven search, in partnership with the data team.

- Powering agentic AI from the data platform — scaling the data foundations behind MystraAI and owning secure, tenant-scoped access for agents, partnering closely with the ML team on how our AI systems perform.

- Treating security as a first-class architectural concern — tenant isolation, secrets and credential management, and least-privilege access to systems, tools and data.

- Setting technical direction, mentoring and line-managing a small team of IC2/IC3 engineers, and influencing decisions well beyond your own team.

WHO YOU ARE

You are a recognised specialist who leads through expertise — principal-level individual-contributor depth combined with the judgement to set standards others follow. You will bring:

- Large-scale OLAP / ClickHouse. Deep experience designing and tuning multi-tenant ClickHouse at extreme scale. You engage with the engine at source level rather than as a black box — and ideally have contributed code upstream.

- Reliability engineering for data platforms. You bring true SRE discipline — SLOs, observability, capacity planning and incident response — to analytical data systems and pipelines.

- Data-as-a-Service productisation. You think in terms of data as a product: secure, multi-tenant, immutable releases, and discoverability at scale.

- Agent-ready data. You understand what it takes to expose platform data to agents safely and at scale — access patterns, tenant isolation, sensible guardrails — and have scaled data infrastructure under demanding workloads.

- Multi-tenant security. You design for isolation, least-privilege access and sound secrets management from the outset.

- Technical leadership. You drive direction and innovation across a platform, mentor engineers, and can line-manage a small team without losing your own hands-on edge.

YOUR PACKAGE

We are committed to providing a transparent, supportive, and rewarding work environment.

COMPENSATION & GROWTH

- Competitive Salary: Salaries are externally benchmarked annually to ensure top-of-market compensation.

- Clear Career Path: A straightforward, open progression framework means you'll always know the path to promotion and how to achieve your next career goal.

- Continuous Learning: Including external courses and a wide library of L&D materials, because your growth is our success.

WELLBEING & TIME OFF

- Holiday: 25 days annual leave, plus bank holidays, plus an extra 3-day company-wide shutdown at year-end.

- Financial & Health Security: Robust benefits including a market-leading pension scheme, comprehensive private health insurance for you and your family with NO excess, critical illness, and life assurance.

- Enhanced Leave: Enhanced paid family leave to support all new parents.

WORK ENVIRONMENT & CULTURE

- Flexible Working: Hybrid Working (e.g., From our London, Oxford Office)

- Truly Inclusive Time Off: Our 'Bank Your Bank Holiday' program allows you to exchange public holidays for dates that hold personal or cultural significance to you.

- Vibrant Social Culture: From regular Town Halls and team picnics to organised sports events, our social committee ensures frequent opportunities to connect and celebrate.

- Green Commute: Cycle-to-Work scheme and convenient office locations near major transport hubs.

Ready to Build the Future?

If this opportunity excites you, apply now!

We are dedicated to creating a diverse environment and are proud to be an equal-opportunity employer. All qualified applicants will receive consideration for employment without…