Software Test Engineer

About this role

Work Schedule: Monday – Friday (with flexibility to meet operational needs), on-site or hybrid (minimum 2d per week onsite)

Location: On-Site in Boulder, CO (Foresight Dx business unit, a Natera company)

Foresight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.

We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.

Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.

What You Will Do:

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Design, develop, and execute test cases based on software requirements, functional specifications, and user needs for laboratory systems

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Perform manual and/or automated testing to validate software functionality, data integrity, and workflow performance in a CLIA-regulated environment

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Partner closely with laboratory operations teams to understand end-to-end workflows and translate them into effective test scenarios

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Identify, document, and track software defects; collaborate with engineering teams to troubleshoot and resolve issues

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Support validation and verification activities for new software releases, system upgrades, and process changes in accordance with CLIA, CAP, NYSDOH, and internal quality standards

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Ensure traceability between requirements, test cases, and validation documentation

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Participate in risk assessments and impact analyses related to software changes affecting laboratory operations

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Contribute to the development and continuous improvement of software testing strategies, SOPs, and documentation practices

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Support audits and inspections by maintaining clear, thorough, and compliant testing documentation

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Act as a quality advocate, ensuring software supports accurate, reliable, and timely patient testing results

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Partner with Operational Excellence to align test strategies with process design, workflow optimization, and scalability initiatives.

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Provide input into system requirements and user stories based on laboratory workflow expertise and testing insights.

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Support critical feedback loops to ensure continuous improvements to software systems.

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Support change management efforts by assessing downstream operational impact of software releases and enhancements.

What You Will Bring:

Minimum Requirements:

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Bachelor’s degree in a scientific discipline (e.g., Biology, Molecular Biology, Bioinformatics) or related field, or equivalent experience

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2+ years of experience in software testing, quality assurance, or validation, preferably in a regulated environment

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Familiarity with NGS workflows and/or clinical laboratory operations (CLIA, CAP, or equivalent)

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Experience writing and executing test cases based on requirements and specifications

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Strong attention to detail and ability to identify edge cases and failure modes

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Excellent documentation skills with a focus on clarity, completeness, and compliance

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Demonstrated ability to translate complex operational workflows into structured test scenarios and validation strategies.

Preferred Qualifications:

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Experience testing LIMS, LIS, or other laboratory software systems

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Knowledge of software development lifecycle (SDLC) and validation frameworks (e.g., CSV, GxP)

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Experience working in high-complexity molecular diagnostics or MRD testing environments

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Familiarity with data validation, NGS file formats (e.g., FASTQ, BAM, VCF), and/or bioinformatics pipelines

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Exposure to test automation tools or scripting (e.g., Python, SQL)

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Experience working cross-functionally with engineering, bioinformatics, and quality teams

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Exposure to regulated change control processes and software impact assessments in regulated environments.

Key…