Senior Manager, US Medical Affairs

About this role

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary:

The Senior Manager, US Medical Affairs supports execution of Dyne’s US Medical Affairs strategy for the Duchenne Muscular Dystrophy (DMD) program. This role contributes to critical launch readiness activities and supports the planning and delivery of US Medical initiatives, including KOL engagement, congress execution, medical education efforts, and cross-functional coordination.

The Senior Manager operates as both a scientific and operational contributor, helping prepare the US Medical organization for anticipated DMD program needs. This role partners closely with Medical Science Liaisons (MSLs), Global Medical Affairs, and cross-functional stakeholders to ensure medical activities are high-quality, compliant, and impactful.

This role is based in Waltham, MA.

Primary Responsibilities Include:

Medical Strategy Execution & Launch Readiness

• Supports execution of US Medical Affairs tactical plans for the DMD program

• Assists in implementing scientific platform materials, congress planning, and medical education initiatives

• Contributes to cross-functional launch readiness activities to ensure alignment with program milestones

• Supports development and deployment of DMD-focused scientific materials, disease state education resources, and field medical tools

Field Medical & KOL Engagement

• Partners with the US MSL team to support KOL identification, engagement planning, insight gathering, and field metric tracking

• Translates field insights into actionable recommendations for Medical Affairs and cross-functional teams

• Tracks and monitors field activity and engagement effectiveness

Scientific Materials & Medical Review

• Contributes to development of scientific materials, field tools, and educational content

• Provides Medical review for promotional materials through the Promotional Review Committee (PRC)

• Maintains…