Senior Director, Global Health Economic & Outcomes Research / Real World Evidenc

About this role

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.
General Description:
The Global HEOR/RWE Senior Director will provide strategic leadership for HEOR and RWE activities supporting BRUKINSA across hematology indications and lifecycle management. This role is accountable for developing and executing integrated value evidence generation strategy to strengthen value proposition and differentiation, support medical, regulatory, commercial and reimbursement needs across key markets. Core responsibilities include comparative effectiveness and real-world evidence generation, JCA/HTA and reimbursement submissions, GVD and AMCP dossiers, indirect comparisons, health economic modeling, and HEOR/RWE data dissemination.
The Senior Director will serve as a key strategic cross-functional partner to medical, commercial, clinical development, and regulatory to ensure aligned evidence generation. This position requires strong research expertise, strategic and innovative thinking with an understanding of reimbursement systems and the evolving treatment landscape, strong communication and presentation skills, and the ability to lead and drive results in a matrix environment.

Essential Functions of the Job:

• Lead and drive global HEOR/RWE strategy and evidence generation activities for BRUKINSA across indications and throughout the product lifecycle, ensuring alignment with cross-functional objectives

• Identify evidence gaps and opportunities, develop and execute integrated value evidence generation plan (including disease burden, treatment patterns, comparative effectiveness, indirect comparisons, economic modeling, and patient-centered outcomes) to strengthen differentiation and demonstrate clinical and economic value

• Design and execute real-world evidence and comparative effectiveness studies using various real-world data sources including claims and electronic health records to support differentiation

• Demonstrate agility in responding to emerging competitor data and evolving evidence needs, including proactively monitor and assess the evolving clinical, competitive, payer, and evidence landscape for BRUKINSA and relevant hematologic malignancies, timely assessment of evidence gaps and development of HEOR/RWE analyses and evidence-generation strategies to support differentiation and value demonstration

• Collaborate with cross-functional partners on payer/JCA/HTA submissions and lead key HEOR deliverables timely including indirect comparisons and economic modeling

• Lead development of Global Value Dossiers and US AMCP dossier to support reimbursement submissions and value communication

• Lead development of health economic models, including cost-effectiveness and budget impact analyses

• Drive HEOR/RWE publication strategy and scientific dissemination of HEOR/RWE evidence through abstracts, manuscripts, congress presentations and omnichannel distributions

• Partner cross-functionally with Clinical Development, Biostatistics, Medical Affairs, Regulatory, Commercial, and Market Access teams to integrate HEOR insights into overall program strategy

• Manage external vendors and research partners, overseeing study design, project executions, deliverables, timelines, and budgets

• Provide strategic HEOR guidance to affiliates and regional teams to support local evidence needs

Supervisory Responsibilities:

• This position may include matrix leadership and oversight of external vendors and consultants

Education Required:

• Advanced degree in Health Economics Outcomes Research (HEOR), Epidemiology, Public Health, Biostatistics, or related discipline

• PhD with 6+ years or Master’s degree with 8+ years of related experience in biopharmaceutical industry or consulting

• Hematology/Oncology experience strongly preferred

Other Qualifications:

• Demonstrated experience serving as HEOR/RWE lead supporting product launch and lifecycle management

• Proven success leading and executing evidence generation strategy and HEOR deliverables

• Strong understanding of global market dynamics and reimbursement landscape, with experiences supporting HTA and/or JCA submissions

• Demonstrated research expertise in designing and conducting HEOR/RWE studies, including indirect comparison, economic models and comparative effectiveness studies, with success in data dissemination and communication

• Impactful communication and presentation skills, with the ability to translate complex data and engage diverse stakeholders

• Innovative thinking and creative mindset with applied AI understanding to enhance evidence generation and HEOR insights

• Highly organized and self-motivated with ability to effectively prioritize and manage multiple projects, determine and meet objectives, timelines, and budget

• Ability to work in a cross-functional matrix team environment and effectively communicate and collaborate relevant HEOR/RWE strategies and activities with internal and external stakeholders

Computer Skills: Proficiency in Microsoft Office, familiarity with statistical software, HEOR modeling tools and AI-enabled approaches for evidence generation and communication

Travel: Up to 15–20% as needed
Global Competencies
When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork

• Provides and Solicits Honest and Actionable Feedback

• Self-Awareness

• Acts Inclusively

• Demonstrates Initiative

• Entrepreneurial Mindset

• Continuous Learning

• Embraces Change

• Results-Oriented

• Analytical Thinking/Data Analysis

• Financial Excellence

• Communicates with…