Scientist, RNA Chemistry

About this role

<div class="content-intro"><h3>Company Overview:</h3> <p>Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at <a href="https://www.dyne-tx.com/">https://www.dyne-tx.com/</a>, and follow us on <a href="https://x.com/dyne_tx">X</a>, <a href="https://www.linkedin.com/company/dynetx/">LinkedIn</a> and <a href="https://www.facebook.com/DyneTherapeutic/">Facebook</a>.</p></div><p><strong>Role Summary:</strong></p> <p data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><span class="TextRun SCXW194020340 BCX8" lang="EN-US" data-contrast="none"><span class="NormalTextRun SCXW194020340 BCX8">The Scientist, RNA Chemistry contributes to the development of Dyne’s oligonucleotide chemistry platform and supports the discovery of novel nucleic acid therapeutics. </span><span class="NormalTextRun SCXW194020340 BCX8">As a member of the Platform team, this role</span><span class="NormalTextRun SCXW194020340 BCX8"> independently designs and executes the synthesis, purification, and characterization of oligonucleotides and their conjugates. The Scientist applies established methodologies, troubleshoots routine technical challenges, and </span><span class="NormalTextRun SCXW194020340 BCX8">leverages</span> <span class="NormalTextRun SCXW194020340 BCX8">expertise</span><span class="NormalTextRun SCXW194020340 BCX8"> in modified RNA synthesis to produce high-quality oligonucleotides using </span><span class="NormalTextRun SCXW194020340 BCX8">state-of-the-art</span><span class="NormalTextRun SCXW194020340 BCX8"> laboratory technologies.</span></span><span class="EOP Selected SCXW194020340 BCX8" data-ccp-props="{"134233117":true,"134233118":true,"335557856":16777215,"335572071":0,"335572072":0,"335572073":0,"335572075":0,"335572076":0,"335572077":0,"335572079":0,"335572080":0,"335572081":0,"335572083":0,"335572084":0,"335572085":0,"335572087":0,"335572088":0,"335572089":0,"469789798":"none","469789802":"none","469789806":"none","469789810":"none","469789814":"none"}"> </span></p> <p data-ccp-border-between="0px none #000000" data-ccp-padding-between="0px"><span data-contrast="none">This position is based in Waltham, MA</span><span data-ccp-props="{"134233117":true,"134233118":true,"335557856":16777215,"335572071":0,"335572072":0,"335572073":4278190080,"335572075":0,"335572076":0,"335572077":4278190080,"335572079":0,"335572080":0,"335572081":4278190080,"335572083":0,"335572084":0,"335572085":4278190080,"335572087":0,"335572088":0,"335572089":4278190080,"469789798":"none","469789802":"none","469789806":"none","469789810":"none","469789814":"none"}"> </span></p> <p> <strong>Primary Responsibilities Include:</strong></p> <ul> <li><span data-contrast="none"><span data-ccp-parastyle="Body" data-ccp-parastyle-defn="{"ObjectId":"b669530d-9cee-5fd4-8da3-4cdbed7bfaa2|1","ClassId":1073872969,"Properties":[469775450,"Body",201340122,"2",134233614,"true",469778129,"Body",335572020,"1",469777841,"Helvetica",469777842,"Helvetica",469777843,"Helvetica",469777844,"Helvetica",469769226,"Helvetica",335551500,"0",268442635,"22"]}">Independently </span><span data-ccp-parastyle="Body">p</span><span data-ccp-parastyle="Body">erform synthesis of modified RNA oligonucleotides</span><span data-ccp-parastyle="Body"> (ASO, siRNAs)</span><span data-ccp-parastyle="Body"> incorporating diverse sugar and backbone chemistries at scales suitable for both in…