Scientist, RNA Chemistry

About this role

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary:

The Scientist, RNA Chemistry contributes to the development of Dyne’s oligonucleotide chemistry platform and supports the discovery of novel nucleic acid therapeutics. As a member of the Platform team, this role independently designs and executes the synthesis, purification, and characterization of oligonucleotides and their conjugates. The Scientist applies established methodologies, troubleshoots routine technical challenges, and leverages expertise in modified RNA synthesis to produce high-quality oligonucleotides using state-of-the-art laboratory technologies.

This position is based in Waltham, MA

Primary Responsibilities Include:

• Independently perform synthesis of modified RNA oligonucleotides (ASO, siRNAs) incorporating diverse sugar and backbone chemistries at scales suitable for both in…