Research Associate II, Pluvinage Lab

About this role

About Arc Institute

Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco.

Unlike academia, our scientists have long-term funding and industry-like resources. Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone.

Our two Institute Initiatives reflect this model in action:

• Virtual Cell Initiative: Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials.

• Alzheimer's Disease Initiative: Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes.

More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding.

About the position

We are seeking a Research Associate to join the Pluvinage Lab at the Arc Institute. Our goal is to improve the lives of patients with neurological diseases. We do this by exploring undiagnosed autoimmunity in rare mystery cases and common neurodegenerative conditions alike. Starting with clinical observations and primary patient tissue, we use functional genomics, protein display technologies, and computational tools to embark on deep mechanistic dives into the contribution of autoimmunity to cognitive function. Your work will have the potential to uncover novel autoantibodies that drive cognitive decline in autoimmune encephalitis, that modulate cognitive decline in dementia, and that promote cognitive resilience in healthy brain aging.

The questions we ask:

• How do autoantibodies regulate cognition?

• What is the source, target, and mechanism of pathogenic autoantibodies in neurological disease?

• How can we eliminate pathogenic autoantibodies while leaving the rest of the immune system intact?

• How does comorbid autoimmunity contribute to cognitive decline in neurodegeneration?

• Are there protective autoantibodies that promote cognitive resilience in healthy brain aging?

The approaches we take: discovery-driven projects starting with human samples (cerebrospinal fluid, PBMCs, brain tissue) from curated cohorts of patients with neurological diseases, CRISPR screens, phage display, immune repertoire sequencing.

In this role, you will work closely with senior lab members to drive high-throughput antibody discovery in autoimmune neurology and neurodegeneration. You will contribute across the full experimental workflow: designing constructs and libraries, cloning and validating reagents, executing screens across several protein display technologies, and analyzing and validating discoveries. This is a hands-on position for someone who enjoys both the precision of molecular biology and the challenge of making complex discovery workflows reproducible and scalable. Your work will help advance new diagnostic approaches from bench to bedside.

About you

• You are detail-oriented and rigorous, taking pride in well-designed experiments, reliable reagents, and reproducible results.

• You are curious and self-motivated, with a strong foundation in molecular biology and an eagerness to learn new protein display and antibody discovery technologies.

• You enjoy working across an entire experimental workflow, from sequence design and cloning to screening and data analysis.

• You are organized and able to manage multiple experiments while maintaining careful sample tracking and documentation.

• You collaborate closely with others, communicate results and challenges openly, and troubleshoot thoughtfully.

• You are passionate about translating discoveries into better diagnostics for patients with neurological disease.

• This position is designed as a training role for individuals preparing to apply to a PhD program. The work associated with this role is expected to last approximately two years, giving you time to build a portfolio of research to support future applications.

In this position you will

• Build Discovery Reagents: Work with senior lab members to design DNA constructs and protein display libraries; perform molecular cloning, sequence verification, and quality control of constructs and libraries.

• Execute High-Throughput Screens: Prepare reagents and patient samples, carry out antibody discovery and antigen-identification workflows across multiple protein display platforms, and maintain rigorous controls and sample tracking throughout.

• Analyze and Validate Discoveries: Process screening data using established analysis workflows, assess data quality and reproducibility, and work with senior lab members to prioritize hits and validate antibody–antigen interactions using complementary assays.

• Develop and Optimize Workflows: Work with senior lab members to troubleshoot experiments, compare assay conditions, and help improve the sensitivity, specificity, throughput, and reproducibility of discovery methods.

• Maintain Research Quality: Keep complete experimental records, document protocols and analysis steps, and maintain organized inventories of samples, constructs, libraries, and reagents.

• Contribute to a Collaborative Lab: Communicate progress at lab meetings, coordinate experiments with senior lab members and collaborators, and contribute to shared lab operations, equipment maintenance, and protocol training.

Requirements

• Bachelor’s or master’s degree in molecular biology, biochemistry, bioengineering, immunology, genetics, or a related field, or equivalent relevant laboratory experience.

• 2+…